Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast
Abstract Background N-hydroxylated base analogs, such as 6-hydroxylaminopurine (HAP) and 2-amino-6-hydroxylaminopurine (AHA), are strong mutagens in various organisms due to their ambiguous base-pairing properties.The systems protecting cells from HAP and related noncanonical purines in Escherichia coli include specialized deoxyribonucleoside triph